Have the gut(s) to test the risk of developing type 2 diabetes mellitus
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INVESTIGATING THE ROLE OF MTNR1B RS4753426 GENETIC VARIANT IN THE TYPE 2 DIABETES MELLITUS RISK
Background: Type 2 diabetes Mellitus (T2DM) is a multifactorial, polygenic disease caused by impaired insulin secretion, insulin resistance and beta-cell dysfunction. Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. Melatonin and the genetic variants of MTNR1B gene are reported to be associated with T2DM susceptibility. We ...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
ASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK
Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes that was classically characterized by pancreatic β-cell dysfunction. Changes in circadian patterns is one of the reasons which can increase the occurrence of diabetes. Melatonin is one of the biological molecules which plays an important role in regulating the circadian clock and also an inhibitory effect on insulin...
متن کاملBlood pressure and risk of developing type 2 diabetes mellitus: the Women's Health Study.
AIMS To examine the relationship of blood pressure (BP) and BP progression with the subsequent development of type 2 diabetes. METHODS AND RESULTS We performed a prospective cohort study among 38 172 women free of diabetes and cardiovascular disease at baseline. Women were classified into four categories according to self-reported baseline BP (<120/75 mmHg, 120-129/75-84 mmHg, 130-139/85-89 m...
متن کاملInsulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in women.
PURPOSE To assess the associations among baseline levels of fasting insulin and proinsulin, proinsulin:insulin ratio, and the development of type 2 diabetes mellitus in apparently healthy middle-aged women. METHODS In a nested case-control study involving a nationwide cohort of 27,628 participants from the Women's Health Study, 126 women with diabetes diagnosed during a 4-year follow-up perio...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2013
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2013.115